Co Armagh murder victim is named locally as Nathan Gibson
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It is understood paramedics worked on Mr Gibson as he lay on the side of the road in central Craigavon last night but were unable to save his life.
Several people have paid tribute to the 25-year-old father of one who was from the Craigavon area.
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Hide AdDetective Inspector Miller said: "Detectives from PSNI Major Investigations Team have commenced a murder investigation following the death of a 25-year-old man in the Lake Road area of Craigavon last night, Thursday 16th January.
"A 40-year-old man has been arrested on suspicion of murder.
"A Post Mortem will be carried out in due course.
"As we carry out our inquiries it is envisaged there will be some disruption to residents and motorists on the Lake Road, Clonmeen areas."
The Lurgan-bound part of the dual carriageway on Lake Road from the roundabout at the entrance to the new South Lakes Leisure Centre has been closed to traffic.
Diversions are in place.
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Hide AdIt is understood areas between Clonmeen and part of Craigavon City Park have been sealed off as forensic scientists comb the area.
Upper Bann MLA Jonathan Buckley said: "This is extremely alarming news coming from Lake Road this morning.
"My first thoughts are with the family and friends of the deceased.